Ucwaningo lwakamuva oluhlanganisa izikhungo eziningi mayelana nokutholakala kwezifo ze-cryptococcal lwenziwe yi-Medical Centre yase-Utrecht University, i-Institute of Biodiversity and Ecosystem Dynamics yase-University of Amsterdam, i-Westerdijk Institute for Fungal Biodiversity, kanye ne-Matogro I-Fungi Research Laboratory ye- I-Federal University of Somalia kanye ne-Júlio Muller University Hospital ye-Federal University of Mato Grosso baqalise ngokuhlanganyela futhi bashicilela isihloko esithi "Ukunganaki izakhi zofuzo" ku-Journal of Clinical Microbiology ngoJanuwari 2021. Ukuhlukahluka kuvimbela ukutholakala ngesikhathi kwe-athikili ye-Cryptococcus.Lesi sihloko siqhathanisa imikhiqizo emine yokutholwa kwegolide ye-cryptococcal colloidal, futhi ihlola ukusebenza kokuxilonga komkhiqizo ngamunye wezinhlobo ezahlukene ze-cryptococcal ngokombono wezinhlobonhlobo zofuzo ze-Cryptococcus neoformans kanye ne-Cryptococcus guttata.Nikeza ngesisekelo esisebenzayo sokuxilonga okusheshayo komtholampilo kwe-Cryptococcus.
Izinhlobo ezine zama-cryptococcal colloidal gold test reagents zasetshenziswa ukuze kuhlolwe uchungechunge lwezinhlobo ezahlukene ezibonisa ukwehlukahlukana kofuzo kwe-cryptococcus, okuhlanganisa imikhiqizo yezinkampani ezine nemikhiqizo ehlanganisa i-Tianjin FungiXpert® kanye ne-IMMY Diagnostics yase-United States.Izinhlobo ezingamashumi amane ze-Cryptococcus ezihlanganisa zonke izinhlobo eziyisikhombisa ezaziwayo kanye nama-interspecific hybrids azo ahloliwe.
Umphumela wocwaningo:
Imiphumela yocwaningo ibonisa ukuthi i-FungiXpert® (umkhiqizo we-Genobio) kanye nekhadi lokuhlola igolide elihlanganisiwe le-IMMY lingathola zonke i-Cryptococcus eziyisikhombisa ezibangela izifo.
Lapho kuhlolwa eminye imikhiqizo emibili yegolide le-colloidal, ezinye izinhlobo ezifana ne-C. bacillisporus, C. deuterogattii, ne-C. tetragattii, ikakhulukazi i-C. tetragattii, zivame ukuthola imiphumela engemihle engamanga.Kodwa-ke, ukutheleleka nge-C. tetragattii kuvamile e-Afrika eseningizimu ye-Sahara nasezwenikazi lase-Indian, elinenani eliphakeme kakhulu lezigameko ze-cryptococcal meningitis ehlobene ne-HIV.Okubalulekile, u-13-20% wezimo ze-cryptococcal meningitis ezihlobene ne-HIV zihlobene ne-C. tetragattii.
Ngokubuka imibiko yakamuva yemiphumela engemihle engamanga ekuhlolweni kwe-cryptococcal e-Botswana nase-Uganda, ababhali baphethe ngokuthi i-C. tetragattii kungenzeka ibe khona kumasampula ocwaningo lwezokwelapha ngale miphumela engemihle engamanga.
Isiphetho sokuhlaziya:
Umbhali uphakamisa ukuthi ekusungulweni noma ekuhlolweni kwezindlela zokuthola i-cryptococcal, i-epidemiology yendawo, isizinda sofuzo kanye nokuhlukahluka kwe-taxonomic kufanele kubhekwe.I-Cryptococcus ye-Pathogenic akufanele ikhawulelwe kusigaba esisodwa se-AD serotypes.Uma kucatshangelwa indlela ebuyekeziwe yokuhlukaniswa kwe-cryptococcal ekwakhiweni komkhiqizo nokuqinisekisa kunganciphisa ukulahlekelwa ukuzwela okubangelwa amanga angamanga.
Ikhadi lokuthola i-cryptococcal capsular polysaccharide (indlela yegolide ye-colloidal) elakhiwe futhi lakhiqizwa yi-Genobio Pharmaceutical Co., Ltd. lamukela indlela yokuthola igolide le-colloidal, elikwazi ukuhlonza ngempumelelo zonke izinhlobo ze-cryptococcal strains.Ukusebenza kulula, futhi imiphumela inembile futhi iyasebenza.Ngemuva kokubona imiphumela yokuhlolwa ingatholakala emizuzwini eyi-10!Nikeza ngesisekelo esinokwethenjelwa kakhulu sokuxilongwa kwangaphambi kwesikhathi futhi okusheshayo kwe-Cryptococcus!
Umthombo we-athikili:
Shi D, Haas PJ, Boekhout T, et al.Ukunganaki ukuhlukahluka kofuzo kuphazamisa ukutholakala ngesikhathi kwezifo ze-Cryptococcus[J].Ijenali yeClinical Microbiology, 2021.
Isixhumanisi se-athikili:
https://journals.asm.org/doi/10.1128/JCM.02837-20
Isikhathi sokuthumela: Jul-28-2021