Amaseli asanda kutheleleka aphethe i-HIV-1 proviral DNA genome ngokuyinhloko ehlanganiswe ku-heterochromatin, okuvumela ukuphikelela kwama-provirus athule ngokubhalwe phansi.I-Hypoacetylation of histone proteins by histone deacetylases (HDAC) ihilelekile ekulondolozeni ukubambezeleka kwe-HIV-1 ngokucindezela ukulotshwa kwegciwane.Ngaphezu kwalokho, izifo ze-periodontal, ezibangelwa amagciwane e-polymicrobial subgingival kuhlanganise ne-Porphyromonas gingivalis, ziphakathi kwezifo ezivame kakhulu esintwini.Lapha sibonisa imiphumela ye-P. gingivalis ekuphindaphindeni kwe-HIV-1.Lo msebenzi ungahle uphatheke kusiko lwebhaktheriya olunamandla kodwa hhayi kwezinye izingxenye zebhaktheriya ezifana ne-fimbriae noma i-LPS.Sithole ukuthi lo msebenzi wokuyenga i-HIV-1 utholwe ku-molecule ephansi yesisindo (<3 kDa) engxenyeni ye-culture supernatant.Siphinde sabonisa ukuthi i-P. gingivalis ikhiqiza ukugxila okuphezulu kwe-butyric acid, esebenza njengesivimbeli esinamandla sama-HDAC futhi ibangele i-histone acetylation.Ukuhlolwa kwe-Chromatin immunoprecipitation kwembula ukuthi i-corepressor complex equkethe i-HDAC1 ne-AP-4 ihlukanisiwe kumgqugquzeli ophindayo we-HIV-1 wetheminali ende lapho ekhuthazwa isiko lebhaktheriya elinamandla kakhulu ngokuhambisana nokuhlotshaniswa kwe-acetylated histone ne-RNA polymerase II.Ngakho-ke sithole ukuthi i-P. gingivalis ingakwazi ukuvuselela i-HIV-1 ngokuguqulwa kwe-chromatin nokuthi i-butyric acid, enye yama-metabolites ebhaktheriya, ibophezele kulo mphumela.Le miphumela iphakamisa ukuthi izifo ze-periodontal zingasebenza njengengcuphe yokuthi i-HIV-1 iphinde isebenze kubantu abanaleli gciwane futhi ingaba nomthelela ekusabalaleni kwegciwane ngendlela ehlelekile.
Isikhathi sokuthumela: Sep-10-2020