Ingabe (1-3)-β-D-glucan Isixhumanisi Esingekho Sisuka Ekuhloleni Eseceleni Kombhede siye Ekwelapheni Kwangaphambi Kokuqothula Kokuhlasela

I-candidiasis engavamile iyinkinga evamile esongela ukuphila ezigulini ezigula kakhulu.Ukuxilongwa kusenesikhathi okulandelwa ukwelashwa ngokushesha okuhloswe ukuthuthukisa umphumela ngokunciphisa ukusetshenziswa okungadingekile kwe-antifungal kuseyinselele enkulu esimweni se-ICU.Ngakho-ke, ukukhetha isiguli ngesikhathi kudlala indima ebalulekile ekuphatheni ngendlela ephumelelayo futhi engabizi kakhulu.Izindlela ezihlanganisa izici zengozi yomtholampilo kanye nedatha ye-Candida colonization ithuthukise ikhono lethu lokuhlonza iziguli ezinjalo kusenesikhathi.Nakuba inani lokubikezela elingalungile lamaphuzu nemithetho yokubikezela lifika ku-95 kuya ku-99%, inani elihle lokubikezela liphansi kakhulu, lisukela phakathi kuka-10 no-60%.Ngakho-ke, uma amaphuzu amahle noma umthetho usetshenziswa ukuqondisa ukuqala kokwelashwa kwe-antifungal, iziguli eziningi zingase zelashwe kungenasidingo.Ama-biomarker e-Candida abonisa amanani aphezulu wokubikezela okuhle;Nokho, abanalo ukuzwela ngakho abakwazi ukubona zonke izimo ze-candidiasis ehlaselayo.Ukuhlolwa kwe-(1-3)-β-D-glucan (BG), ukuhlolwa kwe-panfungal antigen, kunconywa njengethuluzi elihambisanayo lokuxilongwa kwe-mycoses ehlaselayo ezigulini ezinobungozi obukhulu be-hemato-oncological.Iqhaza layo kumphakathi we-ICU ohluke kakhulu kusazochazwa.Amasu okukhetha asebenza kahle emtholampilo ahlanganiswe namathuluzi aselabhorethri asebenzayo ayadingeka ukuze kwelashwe iziguli ezifanele ngesikhathi esifanele ngokugcina izindleko zokuhlolwa nokwelashwa ziphansi ngangokunokwenzeka.Indlela entsha ehlongozwe yi-Posteraro kanye nozakwabo kumagazini wangaphambilini Wokunakekelwa Okubalulekile ihlangabezana nalezi zidingo.Inani elilodwa elihle le-BG ezigulini zezokwelapha ezingeniswe e-ICU ezine-sepsis futhi okulindeleke ukuthi zihlale izinsuku ezingaphezu kwezingu-5 zandulele ukubhalwa kwe-candidemia ngosuku olu-1 kuya kwezingu-3 ngokunemba okungakaze kubonwe ngaphambili.Ukusebenzisa lokhu kuhlolwa kwesikhunta okuyiphuzu elilodwa kusethi ekhethiwe yeziguli ze-ICU ezinengcuphe elinganiselwa ku-15 kuya ku-20% yokuba ne-candidemia kuyindlela ekhangayo futhi engase ibe nezindleko.Uma kuqinisekiswa uphenyo olwenziwa ezindaweni eziningi, futhi kwanwetshwa ezigulini ezihlinzayo ezisengozini enkulu ye-candidiasis ehlaselayo ngemva kokuhlinzwa kwesisu, le ndlela yokuhlukanisa ubungozi esekelwe e-Bayesia okuhloswe ngayo ukukhulisa ukusebenza kahle komtholampilo ngokunciphisa ukusetshenziswa kwezinsiza zokunakekelwa kwezempilo ingase yenze lula ukuphathwa kweziguli ezigula kakhulu ezisengozini. i-candidiasis engavamile.